Update of the consensus document on the aetiology, diagnosis and treatment of acute otitis media and sinusitis.

Update of the consensus on acute otitis media (AOM) (2012) and sinusitis (2013) following the introduction of pneumococcal vaccines in the immunization schedule, and related changes, such as epidemiological variation, colonization by of nonvaccine serotypes and emerging antimicrobial resistances. A majority of studies show that the introduction of the pneumococcal 13-valent conjugate vaccine has been followed by a reduction in the nasopharyngeal carriage of pneumococcus, with an increase in the proportion of drug-resistant nonvaccine serotypes. The diagnosis of AOM is still clinical, although more stringent criteria are proposed, which are based on the visualization of abnormalities in the tympanic membrane and the findings of pneumatic otoscopy performed by trained clinicians. The routine diagnosis of sinusitis is also clinical, and the use of imaging is restricted to the assessment of complications. Analgesia with acetaminophen or ibuprofen is the cornerstone of AOM management; watchful waiting or delayed antibiotic prescription may be suitable strategies in select patients. The first-line antibiotic drug in children with AOM and sinusitis and moderate to severe disease is still high-dose amoxicillin, or amoxicillin-clavulanic acid in select cases. Short-course regimens lasting 5-7 days are recommended for patients with uncomplicated disease, no risk factors and a mild presentation. In allergic patients, the selection of the antibiotic agent must be individualized based on severity and whether or not the allergy is IgE-mediated. In recurrent AOM, the choice between watchful waiting, antibiotic prophylaxis or surgery must be individualized based on the clinical characteristics of the patient.

Actualización del documento de consenso sobre etiología, diagnóstico y tratamiento de la otitis media aguda y sinusitis / Update of the consensus document on the aetiology, diagnosis and treatment of acute otitis media and sinusitis

Actualización de los documentos de consenso de OMA (2012) y sinusitis (2013) tras la introducción de las vacunas antineumocócicas en el calendario vacunal, tras los cambios derivados de las variaciones epidemiológicas, colonización por serotipos no vacunales y la aparición de resistencias. Según la mayoría de los estudios, la introducción de la vacuna antineumocócica conjugada tridecavalente (VNC-13) se ha traducido en un descenso de la colonización nasofaríngea por neumococo, con un aumento porcentual de serotipos resistentes no cubiertos. El diagnóstico de la OMA continúa siendo clínico, aunque se proponen criterios más rigurosos, apoyados en la visualización de alteraciones en la membrana timpánica y la otoscopia neumática realizada por personal entrenado. El diagnóstico rutinario de la sinusitis es clínico y la realización de pruebas de imagen está limitada al diagnóstico de complicaciones asociadas. La analgesia con paracetamol o ibuprofeno es la base del tratamiento en la OMA; la conducta expectante o la prescripción antibiótica diferida podrían ser estrategias adecuadas en pacientes seleccionados. El tratamiento antibiótico de elección en niños con OMA y sinusitis aguda con síntomas moderados-graves continúa siendo la amoxicilina a dosis altas o la amoxicilina-clavulánico en casos seleccionados. En cuadros no complicados, sin factores de riesgo y con buena evolución se proponen pautas cortas de 5-7 días. En pacientes alérgicos se debe individualizar especialmente la indicación de tratamiento antibiótico, que dependerá del estado clínico y si existe o no alergia IgE-mediada. En la OMA recurrente, la elección entre un manejo expectante, profilaxis antibiótica o cirugía se debe individualizar según las características del paciente. (AU)

Update of the consensus on acute otitis media (AOM) (2012) and sinusitis (2013) following the introduction of pneumococcal vaccines in the immunization schedule, and related changes, such as epidemiological variation, colonization by of nonvaccine serotypes and emerging antimicrobial resistances. A majority of studies show that the introduction of the pneumococcal 13-valent conjugate vaccine has been followed by a reduction in the nasopharyngeal carriage of pneumococcus, with an increase in the proportion of drug-resistant nonvaccine serotypes. The diagnosis of AOM is still clinical, although more stringent criteria are proposed, which are based on the visualization of abnormalities in the tympanic membrane and the findings of pneumatic otoscopy performed by trained clinicians. The routine diagnosis of sinusitis is also clinical, and the use of imaging is restricted to the assessment of complications. Analgesia with acetaminophen or ibuprofen is the cornerstone of AOM management; watchful waiting or delayed antibiotic prescription may be suitable strategies in select patients. The first-line antibiotic drug in children with AOM and sinusitis and moderate to severe disease is still high-dose amoxicillin, or amoxicillin-clavulanic acid in select cases. Short-course regimens lasting 5–7 days are recommended for patients with uncomplicated disease, no risk factors and a mild presentation. In allergic patients, the selection of the antibiotic agent must be individualized based on severity and whether or not the allergy is IgE-mediated. In recurrent AOM, the choice between watchful waiting, antibiotic prophylaxis or surgery must be individualized based on the clinical characteristics of the patient. (AU)

Adherence of Spanish pediatricians to "do not do" guidelines to avoid low-value care in pediatrics.

The main objective of this study was to analyze the degree of knowledge and compliance of Spanish pediatricians with the "do not do" recommendations of the Spanish Association of Pediatrics. A nationwide cross-sectional, descriptive study was carried out using a 25-item questionnaire among Spanish pediatricians. Univariate, bivariate, and multivariate analyses were performed. A total of 1137 pediatricians participated in the study. Most of them were women (75.1%), older than 55 (28.3%), worked in specialized care (56.9%), with public financing (91.2%), and had been working for more than 20 years (44.9%). The median of inappropriate answers per question was 9.1%. The bivariate and multivariate analyses showed that the factors that influenced higher adequacy to the "do not do" recommendations were younger than 45 years, working in specialized care, and working in the public health system. CONCLUSION: This research is the first nationwide study in Spain to analyze the adequacy of "do not do" pediatric clinical recommendations. The study showed a high level of compliance by Spanish pediatricians with these recommendations. However, there is a lack of knowledge in less frequent infectious pathologies such as HIV or fungal infections, in not prolonging antibiotic treatment unnecessarily and directing it appropriately according to the antibiogram results. These aspects may be improved by designing measures to enhance pediatricians' knowledge in these specific aspects. Some demographical factors are related to higher adequacy. Performing this research in other countries may allow assessing the current clinical practice of pediatricians. WHAT IS KNOWN: • Low-value care is defined as care that delivers little or no benefit, may cause patients harm, or outcomes marginal benefits at a disproportionately increased cost. • Few nationwide studies have assessed adherence to "do not do" guidelines, especially in pediatric settings. WHAT IS NEW: • Albeit there is a high level of compliance by Spanish pediatricians with the «do not do¼ recommendations, there is a lack of knowledge in different aspects that may be improved. • Some demographical factors are related to higher adequacy. Performing this research in other countries may allow assessing the current clinical practice of pediatricians.

Molecular epidemiology of paediatric invasive pneumococcal disease in Andalusia, Spain.

This study aimed to assess the impact of the introduction of pneumococcal conjugate vaccine 13 (PCV13) on the molecular epidemiology of invasive pneumococcal disease (IPD) in children from Andalusia. A population-based prospective surveillance study was conducted on IPD in children aged <14 years from Andalusia (2018-2020). Pneumococcal invasive isolates collected between 2006 and 2009 in the two largest tertiary hospitals in Andalusia were used as pre-PCV13 controls for comparison of serotype/genotype distribution. Overall IPD incidence rate was 3.55 cases per 100 000 in 2018; increased non-significantly to 4.20 cases per 100 000 in 2019 and declined in 2020 to 1.69 cases per 100 000 (incidence rate ratio 2020 vs. 2019: 0.40, 95% confidence interval (CI) 0.20-0.89, P = 0.01). Proportion of IPD cases due to PCV13 serotypes in 2018-2020 was 28% (P = 0.0001 for comparison with 2006-2009). Serotypes 24F (15%) and 11A (8.3%) were the most frequently identified non-PCV13 serotypes (NVT) in 2018-2020. Penicillin- and/or ampicillin-resistant clones mostly belonged to clonal complex 156 (serotype 14-ST156 and ST2944 and serotype 11A-ST6521). The proportion of IPD cases caused by PCV13 serotypes declined significantly after the initiation of the PCV13 vaccination programme in 2016. Certain NVT, such as serotypes 24F and 11A, warrant future monitoring in IPD owing to invasive potential and/or antibiotic resistance rates.

Deshidratación hipernatrémica grave neonatal por fallo en la instauración de la lactancia materna: estudio de incidencia y factores asociados / Severe neonatal hypernatremic dehydratation in the initiation of the breastfeeding: study of incidence and associated factors

Introducción: la deshidratación hipernatrémica neonatal asociada al fallo en la instauración de la lactancia materna puede provocar importantes complicaciones e incluso la muerte. Existen pocos datos acerca de su magnitud en nuestro medio. Objetivos: conocer la incidencia y describir las características clínico-epidemiológicas asociadas. Material y métodos: estudio observacional retrospectivo en recién nacidos con diagnóstico de deshidratación hipernatrémica con Na>150 mEq/l que necesitaron ingreso hospitalario entre 2011 y 2017 en nuestra área sanitaria. Se excluyeron casos con patología de base o infección concomitante. Se recogieron datos demográficos, clínicos, analíticos, terapéuticos y evolutivos mediante revisión de historias clínicas y se realizó análisis estadístico posterior. Resultados: la población susceptible estimada fue de 41 084 recién nacidos. Cumplieron criterios 20 casos. Alimentación con lactancia materna exclusiva 19/20, primer hijo en 14/20 familias, con mediana de edad materna 34 años (rango intercuartílico: 31-37). Los motivos de consulta más frecuentes fueron pérdida de peso, ictericia e irritabilidad. La mediana de edad al ingreso fue de 5,5 días (rango intercuartílico: 3,3-9,8), con porcentaje de peso perdido 14,4% (rango intercuartílico: 10-17) y natremia mediana 157,25 mEq/L (rango intercuartílico: 152-157,8). La estancia media fue de 6,5 días (rango intercuartílico: 4-8,75), 2/20 precisaron cuidados intensivos. No registramos fallecimientos o complicaciones graves. Conclusiones: la incidencia global de la deshidratación hipernatrémica fue de 0,5 por cada 1000 recién nacidos/año en la población estudiada. Se relacionó con lactancia materna exclusiva, primiparidad y mayor edad materna. Con estos resultados, parece una medida oportuna informar sobre signos de alarma al alta de maternidad, así como realizar la primera revisión del bebé de forma precoz

Introduction: neonatal hypernatremic dehydration associated with failure in the establishment of breastfeeding instauration can cause significant complications and even death. There are few studies on its incidence in Spain. Objectives: our aim was to determine the incidence of this problem and describe the epidemiological and clinical features associated with it. Materials and methods: we conducted a retrospective observational study in newborns with a diagnosis of hypernatremic dehydration and serum sodium levels of more than 150 mEq/l that required hospitalization between 2011 and 2017 in our catchment area. We excluded patients with underlying conditions or concomitant infection. We collected data on epidemiological, clinical, laboratory, treatment and outcome variables through the review of health records, followed by their statistical analysis. Results: the estimated size of the susceptible population was 41 084 newborns. Twenty met the inclusion criteria. In this sample, 19/20 newborns were exclusively breastfed, 14/20 were the first-born child, and the median maternal age was 34 years (interquartile range: 31-37). The most frequent reasons for seeking care were weight loss, jaundice and irritability. The median age at admission was 5.5 days (interquartile range: 3.3-9.8), the percentage of birth weight lost was 14.4% (interquartile range: 10-17), and the median serum sodium level was 157.25 mEq/l (interquartile range: 152-157.8). The mean length of stay was 6.5 days (interquartile range: 4-8.75), and 2/20 newborns required intensive care. None of the patients died or had severe complications. Conclusions: we found an overall incidence of hypernatremic dehydration of 0.5 per 1000 live births per year in the population under study. We found an association with exclusive breastfeeding, primiparity and greater maternal age. In light of these results, it seems advisable to provide information on the warning signs at the time of discharge from the maternity ward, and to schedule the first checkup for the baby at an earlier time

Neuritis óptica en la infancia. Casuística, revisión de la bibliografía y propuesta de tratamiento / Optic neuritis in childhood. A pediatric series, literature review and treatment approach

Introducción. En la edad pediátrica, la forma más frecuente de neuritis óptica se presenta generalmente después de un cuadro infeccioso, con edema de papila, que suele ser bilateral y tiene buen pronóstico. La conversión a esclerosis múltiple es infrecuente. Objetivo. Presentar las características clínicas y de laboratorio de una serie pediátrica de neuritis óptica. Pacientes y métodos. Se analiza una serie de 17 casos de neuritis óptica en niños y jóvenes de 4 a 14 años, referidos entre los años 2000 y 2015. Resultados. La edad mediana de la serie fue de 11 años. Predominaron los pacientes de sexo femenino y el antecedente infeccioso fue poco frecuente; en cinco pacientes, la afectación fue bilateral, y cuatro casos se presentaron como neuritis óptica retrobulbar. La resonancia magnética mostró hiperintensidad en T2 en los nervios ópticos afectados en cinco pacientes. El estudio del líquido cefalorraquídeo y bandas oligoclonales fue normal en todos los casos. Los pacientes, tratados con metilprednisolona intravenosa, tuvieron buena recuperación. Sólo en tres casos se comprobó una evolución posterior a esclerosis múltiple. Conclusiones. En esta serie, los casos que evolucionaron a esclerosis múltiple no mostraron diferencias clínicas, aunque sí presentaron mayor cantidad de lesiones hiperintensas en la resonancia magnética. Este hecho, descrito en trabajos previos, apoya nuestro esquema diagnóstico y terapéutico en un intento por acercarnos al manejo óptimo de esta patología (AU)

Introduction. In children, the most common form of optic neuritis usually occurs after an infectious disease with papilledema, usually bilateral and has a good prognosis. Conversion to multiple sclerosis is low. AIM. To present clinical and laboratory case of optic neuritis in pediatrics features. Patients and Methods. Seventeen clinical cases of optic neuritis in children and young people aged 4-14 years, referred from 2000 to 2015 were analyzed. Results. The median age of the series was 11 years. They predominated the female patients and infectious history was uncommon; in five of 17 patients was bilateral engagement and four cases evolved with retrobulbar optic neuritis. Magnetic resonance imaging showed hyperintensity on T2 in the optic nerves affected in five patients. The study of cerebrospinal fluid and oligoclonal bands was normal in all cases. Patients treated with intravenous methylprednisolone had good recovery. It was found subsequent evolution to multiple sclerosis only in three cases. Conclusions. In our series, the cases that evolved multiple sclerosis showed no clinical differences although they had a higher number of hyperintense lesions on magnetic resonance imaging. This fact, described in previous studies, supports our diagnostic and therapeutic scheme in an attempt to approach the optimal management of this disease (AU)